| Mifepristone
(RU 486) |
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| • | Synthetic
steroid that prevents progesterone from |
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| binding to
progesterone and glucocorticoid receptors |
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| • | Mechanism(s)
of action |
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| – | Disrupts
follicular maturation and endocrine |
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| function of
the granulosa cell |
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| – | Disrupts
midcycle LH surge |
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| – | Interrupts
hormonal support of the endometrium, |
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| making it
asynchronous |
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|
|
|
| LaValleur
J. Obstet Gynecol Clin North
Am. 2000;27(4): 817-839. |
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| Marions L, et al.
Obstet Gynecol 2002;100:65-67. |
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| Glasier
A, et al. N Engl J Med. 1992;
327(15):1041-1044. |
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