Transport from the ER to the Golgi
When the protein is properly folded, COPII coated
vesicles transport the proteins via the vesicular tubular
cluster (vtc) to the cis-Golgi network.
•
The COPII coating is removed
(Sar1 hydolyzes GTP) and the
vesicles fuse with each other
to form the vtc.
•
The vtc is motored along
microtubules that function like
railroad tracks.
•
The vtc fuses with the cis-
Golgi network.