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Department of Molecular and Cell Biology Title: "Activation of Enhancer Activity in the Early Drosophila Embryo" Abstract: Thirty years after the discovery of the transcriptional enhancers that drive patterned gene expression in animal embryos, we still do not really understand how they work. One mystery is why it is that there are potential transcription factor binding sites everywhere, but only a small fraction of the genome functions as enhancers. I will talk about recent work in our lab that suggests that the conventional explanation for this phenomenon - that enhancers are found where binding sites are organized in a specific manner - does not explain available data, and instead that, in the early fly embryo at least, there are parallel systems involving different sets of factors and processes that determine where enhancers are located and what patterns they encode.
Host: Dr. Molly Przeworski |
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