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DR. LEONARD MINDICH Public Health Research Institute New Jersey Medical School Rutgers University Title: “Precise packaging of complex viral genomes and the temporal control of their gene expression” Article Abstract Several families of viruses that infect eukaryotic cells contain segmented RNA genomes. The mechanisms that they utilize to precisely package these genomes are not known. A family of bacteriophages, the Cystoviridae, have genomes of three segments of dsRNA. The packaging mechanism has been determined and involves the sequential conformational changes in the procapsid structure as RNA is incorporated into the particle. The genomic segments are transcribed by a polymerase located in the interior of virus particle. The template specificity of the viral polymerase is modified by the binding of specifichost proteins to the exterior of the viral capsid so as to result in a temporal control of gene expression during infection. Host: Dr. Alex Tzagoloff |
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